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KMID : 1134820060350091172
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Journal of the Korean Society of Food Science and Nutrition
2006 Volume.35 No. 9 p.1172 ~ p.1177
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Effects of Araliaceae on Lipid Levels of Plasma and Liver in Streptozotocin?Induced Diabetic Rats
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Shin Kyung-Hee
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Abstract
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This study was conducted to investigate the effects of Araliaceae water extracts on lipid concentrations in streptozotocin (STZ)-induced diabetic rats. The Male Wistar rats were divided into normal and diabetic group. The diabetic group was futher subdivided into the control group (DM) and the Araliaceae water extracts supplemented group: Aralia elata (AE), Acanthopanacis cortex (AC) and Ulmus davidiana (UD). The extracts were supplemented with 1.14% of raw Araliaceae/㎏ diet for 7 weeks. Diabetes was induced by injecting STZ (55 ㎎/㎏ B.W., i.p.) once 2 weeks before sacrifying. The net weight gain and feed efficiency ratio were significantly lower in the STZ-induced diabetic group than in the normal group. However, all of the Araliaceae water extracts supplemented groups resulted in an increase of body weight compared to the DM group. The triglyceride, total cholesterol and free cholesterol concentrations in plasma and liver were significantly higher in the DM group than in the normal group. However, the supplementation of Araliaceae water extracts increased plasma HDL-cholesterol concentration, while decreased plasma VLDL, LDL-cholesterol concentra-tions in Araliaceae water extracts supplemented group.
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KEYWORD
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Aralia elata, Acanthopanax cortex, Ulmus davidiana var. japonica, streptozotocin, lipid profile
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